Causes, Mold: Prevention, Kensler clip 2
Professor Kensler explains that there is a lot of interest in discovering new classes of chemopreventative agents and foods such as, fruits and vegetables appear to be a very rich source.
Thomas Kensler, Ph.D. is a professor at John Hopkins Bloomberg School of Public Health. His research focuses on the molecular mechanisms involved in the development of cancers linked to exposure to environmental carcinogens. This research has led to potential chemopreventative strategies for liver cancer in populations at high risk for aflatoxin exposure. â€œThere is a lot of interest in discovering new classes of chemopreventative agents, and foods, fruits, and vegetables in particular appear to be a very rich source. So, we know of at least a hundred natural compounds that work through the molecular mechanism that we're trying to target â€“ increased expression of detoxification enzymes. But, there are many other compounds that work through other pathways that also show great promise. And in fact, perhaps, the greatest promise will come in combinatorial approaches where we take agents with distinct mechanisms of action and put them together to really try and knock down the precancerous cells.â€
detoxification enzymes, john hopkins bloomberg school of public health, environmental carcinogens, natural compounds, distinct mechanisms, precancerous cells, liver cancer, fruits and vegetables, combinatorial approaches, molecular mechanisms, school of public health, molecular mechanism, aflatoxin, rich source, high risk, cancers, pathways, mold
- ID: 998
- Source: DNALC.IC
In this section learn about inexpensive and safe substances being investigated that may decrease the risk of liver cancer.
Aflatoxin, a byproduct of molds, is a potent cancer-causing agent. Long-term exposure to aflatoxin has been linked to increased incidence of liver cancer.
Professor Kensler explains that the importance of aflatoxin and the causation of liver cancer results from a life long series of exposures.
Professor Kensler explains that Aflatoxin is a lipid soluble molecule that is rapidly absorbed and it goes first to the liver where there are enzymes that will chemically biotransform it into a very reactive chemical.
In this section learn how Aflatoxin a contaminating byproduct of mold caused liver cancer in animals and solicited strict guidelines to regulate the levels of Aflatoxin in the U.S. food supply today.
Aflatoxin causes DNA damage and with prolonged exposure to aflatoxin, cells accumulate DNA mutations and thus are at increased risk of developing into cancer cells.
Professor Kensler explains their clinical trials in which chlorophyllin was administered as a therapy and the resultant levels of aflatoxin DNA damage products present in urine samples.
Professor Groopman explains that Aflatoxin is produced by a variety of molds and these molds contaminate the grains either outside or they can actually penetrate inside the grains.
Professor Groopman explains that we have an effective vaccine against the hepatitis B virus, but because the transmission of this virus occurs very early in life, we need to have the resources and the ability to vaccinate the world for the rest of the 21s
Mold-contaminated crops can be a serious problem especially in countries where proper storage facilities are limited.