Causes, Mold: Aflatoxin, Groopman
Professor Groopman explains that Aflatoxin is produced by a variety of molds and these molds contaminate the grains either outside or they can actually penetrate inside the grains.
John Groopman, Ph.D. is the Chair of the Department of Environmental Health Sciences at John Hopkins Bloomberg School of Public Health. His research focuses on the molecular causes and effects of environmental factors that may lead to the development of cancers. This research has led to the development of biomarkers used in studies of high-risk aflatoxin-hepatitis B populations specifically in China. â€œAflatoxin is produced by a variety of molds and these molds contaminate the grains either outside or they can actually penetrate inside the grains. And then aflatoxin itself is a metabolite, it's actually a product that the mold produces that is then excreted out and contaminates the grain. The toxicity of aflatoxin and its potency as a carcinogen was recognized very early in the 1960s and as a consequence the U.S. Food and Drug Administration and the U.S. Department of Agriculture put in place regulations very early on in the studies of this compound to regulate the levels of aflatoxin that would be permitted in the food supply. It was further recognized that just the physical examination of a corn grain product, or peanut butter, or peanut product was inadequate to determine whether aflatoxin was present. And only a specific chemical analysis of the grain or grain product could be performed in order to determine if aflatoxin was really there.â€
john groopman, john hopkins bloomberg school of public health, bloomberg school of public health, environmental health sciences, food and drug administration, corn grain, grain product, aflatoxin, hepatitis b, school of public health, biomarkers, carcinogen, metabolite, environmental factors, molds, food supply, physical examination, high risk
- ID: 990
- Source: DNALC.IC
In this section learn how Aflatoxin a contaminating byproduct of mold caused liver cancer in animals and solicited strict guidelines to regulate the levels of Aflatoxin in the U.S. food supply today.
Aflatoxin, a byproduct of molds, is a potent cancer-causing agent. Long-term exposure to aflatoxin has been linked to increased incidence of liver cancer.
Professor Groopman explains that we have an effective vaccine against the hepatitis B virus, but because the transmission of this virus occurs very early in life, we need to have the resources and the ability to vaccinate the world for the rest of the 21s
Mold-contaminated crops can be a serious problem especially in countries where proper storage facilities are limited.
Professor Kensler explains that Aflatoxin is a lipid soluble molecule that is rapidly absorbed and it goes first to the liver where there are enzymes that will chemically biotransform it into a very reactive chemical.
Professor Kensler explains their clinical trials in which chlorophyllin was administered as a therapy and the resultant levels of aflatoxin DNA damage products present in urine samples.
Professor Kensler explains that there is a lot of interest in discovering new classes of chemopreventative agents and foods such as, fruits and vegetables appear to be a very rich source.
Professor Kensler explains that the importance of aflatoxin and the causation of liver cancer results from a life long series of exposures.
In this section learn about inexpensive and safe substances being investigated that may decrease the risk of liver cancer.
Aflatoxin causes DNA damage and with prolonged exposure to aflatoxin, cells accumulate DNA mutations and thus are at increased risk of developing into cancer cells.