Causes, Mold: Aflatoxin action, Kensler
Professor Kensler explains that the importance of aflatoxin and the causation of liver cancer results from a life long series of exposures.
Thomas Kensler, Ph.D. is a professor at John Hopkins Bloomberg School of Public Health. His research focuses on the molecular mechanisms involved in the development of cancers linked to exposure to environmental carcinogens. This research has led to potential chemopreventative strategies for liver cancer in populations at high risk for aflatoxin exposure. â€œI believe the importance of aflatoxin and the causation of liver cancer results from a life long series of exposures. Intermittent sort of random exposures are not likely to sort of tip the balance and create the cancer cells; our defense mechanisms are pretty good for those very low levels and intermittent levels of exposure. But there is a chronic long-term exposure through the diet in many of these high-risk areas. In turn that means we need a chronic long term commitment to a preventive intervention. We need an intervention that people could take every day or at least several times a week, but not just for weeks to make the problem go away, but for the rest of their lives. For as long as the aflatoxin exposure is there, the need for the countermanding or intervention approach is also very important.â€
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- ID: 995
- Source: DNALC.IC
Aflatoxin causes DNA damage and with prolonged exposure to aflatoxin, cells accumulate DNA mutations and thus are at increased risk of developing into cancer cells.
Aflatoxin, a byproduct of molds, is a potent cancer-causing agent. Long-term exposure to aflatoxin has been linked to increased incidence of liver cancer.
Professor Kensler explains that Aflatoxin is a lipid soluble molecule that is rapidly absorbed and it goes first to the liver where there are enzymes that will chemically biotransform it into a very reactive chemical.
In this section learn about inexpensive and safe substances being investigated that may decrease the risk of liver cancer.
Professor Kensler explains that there is a lot of interest in discovering new classes of chemopreventative agents and foods such as, fruits and vegetables appear to be a very rich source.
Professor Kensler explains their clinical trials in which chlorophyllin was administered as a therapy and the resultant levels of aflatoxin DNA damage products present in urine samples.
In this section learn how Aflatoxin a contaminating byproduct of mold caused liver cancer in animals and solicited strict guidelines to regulate the levels of Aflatoxin in the U.S. food supply today.
Professor Groopman explains that Aflatoxin is produced by a variety of molds and these molds contaminate the grains either outside or they can actually penetrate inside the grains.
Mold-contaminated crops can be a serious problem especially in countries where proper storage facilities are limited.
Professor Groopman explains that we have an effective vaccine against the hepatitis B virus, but because the transmission of this virus occurs very early in life, we need to have the resources and the ability to vaccinate the world for the rest of the 21s