Dopamine and Serotonin Systems and Disorder
Doctor Randy Blakely discusses the role of the dopamine and serotonin systems in a number of clinical disorders.
Work in the field now is beginning to reveal that the neurochemistry of the brain, particularly studies looking at the actions of metabolic hormones like insulin and other endocrine hormones, can influence the availability of these transporter proteins. It makes some sense; you probably know that the dopamine transporter is a major target for drugs of abuse, like cocaine, and that the dopamine system â€“ one component of the dopamine system â€“ is involved in reward mechanisms and reinforcement. Well, one of the major reinforcements that we have is eating, and eating food makes us feel good. It doesnâ€™t make us feel good just because we have food in our stomachs; it makes us feel good because our brain has received signals that tell us that we now have had enough to eat, or weâ€™ve eaten good food. The brain and the periphery communicate, and that leaves open the possibility that, perhaps, certain disorders that are linked to, letâ€™s say, inappropriate diet or metabolism, could influence the way the dopamine system is working and the dopamine transporter is working. You could make a similar case for serotonin; dietary control of serotonin systems in the brain has been something that has been known for a long time. In fact, clinicians use tryptophan, an amino acid; they deplete tryptophan in patients who have, say, a mood disorder like depression, and they can cause remission of the depression, they can cause the depression to come back, simply by taking away this amino acid in these patients. Thatâ€™s a major lesson, and there are others that weâ€™ve come across recently. For example, if you have the indications of an infection or an inflammation in the periphery, your brainâ€™s serotonin system will respond. It may be part of a mood change that occurs during things like an inflammatory disorder or the flu. So, our brain is very tightly connected with the rest of our bodies, and what we do to protect our health, our nutrition state, our social behavior, our position in society and in the world, does influence these critical neurotransmitters in the brain.
dopamine, serotonin, neurotransmitter, systems, diet, mood, disorder, neurochemistry, amino acid, hormones, randy, blakely
Professor Randy Blakely explains that biogenic amines include transmitters like serotonin, dopamine, and norepinephrine. Transporters assist these amines at synapses.
Doctor Randy Blakely introduces biogenic amines transporters, which remove biogenic amines such as serotonin, dopamine, and norepinephrine from extracellular space, keeping the path clear for the next pulse of neurotransmitter.
Doctor Randy Blakely speculates that the traditional view that drugs though to increase serotonin and dopamine levels in the brain may work by preventing a backward-running state.
Although writers have described episodes of depression since antiquity, only recently have we recognized that the depressive disorders are among the most common and disabling medical conditions throughout the world.
Professor Wayne Drevets explains how positron emission tomography (PET) is used to examine biochemicals in the brain such as serotonin.
Serotonin is the biochemical most commonly associated with depression. Professor Wayne Drevets discusses other systems including norepinephrine, glutamate, and dopamine.
Doctor Randy Blakely interprets the high success rate in treating ADHD with drugs as evidence of a common mechanism underlying the disorder that these drugs are attacking
Doctor Ellen Leibenluft discusses some of the biochemicals that have been associated with bipolar disorder, including dopamine, serotonin, and glutamate.
Doctor Randy Blakely discusses the potential role of the dopamine transporter (DAT) as one element of a complex protein network in ADHD and bipolar disorder.
Professor Pat Levitt discusses how stress affects the biochemistry of the brain and plays a major role in most cognitive disorders.