A Common Mechanism for Treating ADHD
Doctor Randy Blakely interprets the high success rate in treating ADHD with drugs as evidence of a common mechanism underlying the disorder that these drugs are attacking
There is certainly a large number of kids with ADHD who respond well to methylphenidate, which is a blocker of the dopamine transporter, or amphetamine, which, as I mentioned, can cause this reverse transport of dopamine. That high success rate leads you to believe that there is a common mechanism underlying ADHD that these drugs are attacking. The question is: what is that mechanism? Now, the two boys that we found this mutation in certainly do not constitute 70 to 80 percent of ADHD kids out there. These are rare mutations; we may never find another child with this particular mutation. But it doesnâ€™t matter, because we have now cracked through into an understanding of a mechanism where amphetamine and methylphenidate actually converge on a common property, with regard to dopamine, and that is in blocking this outward movement of dopamine, when you have a dopamine transporter thatâ€™s misbehaving.
adhd, mediucation, amphetamine, treatment, mutations, dopamine transporter, methylphenidate, randy, blakely
Doctor Randy Blakely speculates that the traditional view that drugs though to increase serotonin and dopamine levels in the brain may work by preventing a backward-running state.
Doctor Randy Blakely describes an intriguing hypothesis for why amphetamine may be effective in treating some individuals with ADHD.
Doctor Randy Blakely discusses the association between the dopamine transporter and ADHD, and discusses a possible relationship with bipolar disorder and schizophrenia.
Professor Trevor Robbins discusses ADHD in relation to noradrenaline and dopamine, both of which are enhanced by ADHD medications such as Ritalin.
Professor Trevor Robbins discusses whether ADHD is a disorder of the noradrenaline system.
Doctor Randy Blakely discusses the potential role of the dopamine transporter (DAT) as one element of a complex protein network in ADHD and bipolar disorder.
Professor Philip Shaw discusses some medications use to treat ADHD, which lead to improvements in up to 90% of children.
Professor Randy Blakely explains that biogenic amines include transmitters like serotonin, dopamine, and norepinephrine. Transporters assist these amines at synapses.
Doctor Randy Blakely introduces biogenic amines transporters, which remove biogenic amines such as serotonin, dopamine, and norepinephrine from extracellular space, keeping the path clear for the next pulse of neurotransmitter.
All children have occasional trouble paying attention or suppressing their impulses. ADHD is a chronic condition, however, and its main symptoms have a larger effect on people’s lives.