Biogenic Amine Transporters
Doctor Randy Blakely introduces biogenic amines transporters, which remove biogenic amines such as serotonin, dopamine, and norepinephrine from extracellular space, keeping the path clear for the next pulse of neurotransmitter.
Biogenic amine transporters are membrane proteins that assist in the ability of these small molecules called biogenic amines, like serotonin, dopamine, and norepinephrine, to act at brain synapses. When these molecules are released, they need to have a finite duration of action, and their action should not spread very far beyond an initial synapse or a small set of synapses, and these biogenic amine transporters are proteins that remove the neurotransmitters from the extracellular space and keep the path clear for the next arriving pulse of neurotransmitter.
brain synapses, dopamine and norepinephrine, finite duration, membrane proteins, extracellular space, amines, neurotransmitters, synapse, biogenic amine, randy, blakely
Professor Randy Blakely explains that biogenic amines include transmitters like serotonin, dopamine, and norepinephrine. Transporters assist these amines at synapses.
Professor Randy Blakely discusses the impact of gene variation (polymorphisms) on transporter proteins. Impact can be very subtle and is linked to regulatory processes.
Doctor Jon Lieberman discusses three neurotransmitters that have been associated with depression - dopamine, serotonin, and norepinephrine.
Doctor Randy Blakely speculates that the traditional view that drugs though to increase serotonin and dopamine levels in the brain may work by preventing a backward-running state.
Doctor Randy Blakely discusses the potential role of the dopamine transporter (DAT) as one element of a complex protein network in ADHD and bipolar disorder.
Doctor Randy Blakely describes an intriguing hypothesis for why amphetamine may be effective in treating some individuals with ADHD.
Doctor Randy Blakely discusses the role of the dopamine and serotonin systems in a number of clinical disorders.
Doctor Gul Dolen defines synapse-opathies as disease where the synapse is the part of the brain that is disrupted. Fragile X and autism are examples.
The UNC18 protein, also known as A0238, is involved in the regulation of vesicle release from the synaptic membrane and is essential to neurotransmission.
Professor Jeffrey Lieberman discusses the dopamine hypothesis, the predominant neurochemical theory of schizophrenia.