Biochemistry of ADHD - dopamine
Professor Philip Shaw links an association between ADHD and dopamine receptors, which may relate to brain development.
The risk variation of the dopamine D4 receptor has in some studies been shown to make the receptor a little bit less sensitive to dopamine in the brain. Now how that would translate into changes in the brain cortex we donâ€™t know yet, but itâ€™s not inconceivable that it does. So there does seem to be a physiological difference of this genetic variation, which is very interesting, and the work now remains linking that to how the cortex develops. We know, for example, from other studies, that dopamine fluxes in the brain and dopamine regulation in the brain is very much intimately associated with how the cortex develops. So, it would certainly not be inconceivable to link the two together in the future.
adhd, attention, biochemistry, deficit, hyperactivity, disorder, dopamine, receptor, philip, shaw
Professor Philip Shaw discusses the relationship between serotonin and ADHD.
An overview of ADHD-related content on Genes to Cognition Online.
An overview of attention-related content on Genes to Cognition Online.
Professor Philip Shaw rebuffs the myth that ADHD is not a serious disorder.
Professor Philip Shaw discusses research into ADHD diagnosis, which suggests the disorder is under- rather than over-diagnosed.
Professor Philip Shaw discusses his team's research linking ADHD with a variant of the DRD4 gene, which is also associated with brain development.
Professor Philip Shaw discusses some medications use to treat ADHD, which lead to improvements in up to 90% of children.
Professor Philip Shaw discusses some clinical and behavioral treatments for ADHD, which may work best when combined with medication.
New research implicates genetically altered dopamine transporters in ADHD.
Professor Pat Levitt discusses that although it shares genes with other disorders, schizophrenia is likely caused by unique combinations of genes.