Genes and Schizophrenia
Professor Pat Levitt discusses that although it shares genes with other disorders, schizophrenia is likely caused by unique combinations of genes.
The genes that are implicated in schizophrenia, some of them have been implicated in other neuropsychiatric disorders, like bipolar disorder for example. Genes that are responsible for building the connections between nerve cells have been implicated both in schizophrenia and in bipolar disorder. There are genes that have been implicated in schizophrenia, for example those that are responsible for certain kinds of neurotransmitters like dopamine. They have been implicated in attention deficit hyperactivity disorder as well. So there are some examples. But the bottom line is we think there are going to be relatively unique combinations of genes that cause vulnerability for each of the disorders.
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Professor Pat Levitt explains that the genetic basis for ADHD is evident from twin and family studies.
An overview of ADHD-related content on Genes to Cognition Online.
Professor Philip Shaw links an association between ADHD and dopamine receptors, which may relate to brain development.
An overview of attention-related content on Genes to Cognition Online.
Doctor Randy Blakely discusses the association between the dopamine transporter and ADHD, and discusses a possible relationship with bipolar disorder and schizophrenia.
Professor Pat Levitt explains that twin studies of autism show that it is a highly genetic disorder.
Professor Pat Levitt comments that people with genetic vulnerability to schizophrenia often have developmental problems from an early age.
All children have occasional trouble paying attention or suppressing their impulses. ADHD is a chronic condition, however, and its main symptoms have a larger effect on people’s lives.
New research implicates genetically altered dopamine transporters in ADHD.
Professor Judith Rapoport describes attempts to define cellular abnormalities in ADHD as something of a black hole, which may be due to the polygenic nature of the disorder.