Serotonin reuptake inhibitors (SSRIs)
Professor James Potash discusses recent findings that question the effectiveness of serotonin reuptake inhibitors (SSRIs).
Studies of antidepressant medications have been going on for 50 years and in general the antidepressant medications seem to work about sixty percent of the time. Now, a placebo typically works thirty percent of the time, so generally the antidepressants help. There have been some meta-analyses of recent data that show that that gap between antidepressant effect and placebo effect is smaller than some of the older studies have showed. Some of the meta-analyses have shown that the statistically significant difference between medication and placebo only applies to cases where depression is more severe. That seems to me to be a reasonable conclusion because certainly cases of milder depression do sometimes resolve on their own and sometimes they resolve with psychotherapy, and placebo to a certain extent constitutes a form of psychotherapy.
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Doctor Jon Lieberman discusses the propsed mechanism of Selective Serotonin Reuptake Inhibitors (SSRIs), a controversial treatment for depression.
Professor Wayne Drevets discusses the serotonin system in relation to depression. Drugs that block serotonin reuptake in the brain (SSRIs) are commonly used to treat depression.
Professor Wayne Drevets examines the efficacy of selective serotonin reuptake inhibitors (SSRIs) in treating depression. Not all patients respond well to SSRIs and may need different treatments.
An overview of depression-related content on Genes to Cognition Online.
Although writers have described episodes of depression since antiquity, only recently have we recognized that the depressive disorders are among the most common and disabling medical conditions throughout the world.
Professor James Potash concludes that any good treatment for depression does involve some element of psychotherapy.
A review of antidepressant medications.
The 5-HTT gene has been associated with both depression and autism.
Serotonin is the biochemical most commonly associated with depression. Professor Wayne Drevets discusses other systems including norepinephrine, glutamate, and dopamine.
A review of the symptoms, causes, diagnosis, and treatments of bipolar disorder.