The RNA message is sometimes edited.
The Sambrook lab at Cold Spring Harbor Laboratory around 1971 where Phil Sharp was a post-doc. (L-R) Arlene Jackson, Phil Sharp and C. Mulder.
Recounting how he came to Cold Spring Harbor Laboratory to study viruses.
Describing long nuclear versus short cytoplasmic message RNA, and what the differences suggested.
Interpreting the electron micrographs that led to the discovery of the split gene.
Developing the experimental technologies used to study DNA fragments: agarose gel electrophoresis and restriction enzymes.
Commenting on how the real excitement of science comes when you don't know what's going on, and you get to be part of "the chase."
Phil Sharp and Richard Roberts shared the 1993 Nobel Prize for the discovery of the split gene theory.
Dr. Sharp explains the process of RNA splicing.
Drs. Sharp and Sumner describe how RNA splicing can be used as a therapy for SMA.