Video 24: Phil Sharp, clip 5
Phil Sharp is the Salvador E. Luria Professor of Biology at the Massachusetts Institute of Technology. His laboratory studies both the catalytic processes responsible for splicing and the nature of the factors conferring specificity.
massachusetts institute of technology, catalytic processes, luria, laboratory studies, specificity, rna, biology,
- ID: 16547
- Source: DNALC.DNAFTB
- Download: MPEG 4 Video
Developing the experimental technologies used to study DNA fragments: agarose gel electrophoresis and restriction enzymes.
Describing long nuclear versus short cytoplasmic message RNA, and what the differences suggested.
Interpreting the electron micrographs that led to the discovery of the split gene.
Recounting how he came to Cold Spring Harbor Laboratory to study viruses.
Phil Sharp and Richard Roberts shared the 1993 Nobel Prize for the discovery of the split gene theory.
David Baltimore, Howard Temin and Renato Dulbecco shared the 1975 Nobel Prize in Physiology or Medicine for the discoveries concerning the interaction between tumor viruses and the genetic material of the cell.
Robert Horvitz, Whitehead Professor of Biology, Massachusetts Institute of Technology.
Igor Dawid did some of the first differential gene expression studies using cDNA subtraction.
Thomas Cech and Sidney Altman discovered that RNA can have enzymatic activities. For this discovery, they shared the 1989 Nobel Prize for Chemistry.
Doug Hanahan refined transformation methods for DNA uptake into bacteria.