What is sickle cell?

Mutations in the HBB gene on chromosome 11 can cause sickle cell. The beta globin protein is one of the subunits of hemoglobin, a protein necessary for the oxygen-carrying function of red blood cells. People with the sickle cell mutation in both copies of the HBB gene produce proteins that clump together and lead to changes in the shape and behavior of red blood cells.

red blood cells,function of red blood cells,sickle cell mutation,chromosome 11,clump,hemoglobin,subunits,mutations,proteins,oxygen,protein,shape,beta globin

  • ID: 15967
  • Source: DNALC.DNAi

Related Content

15968. What causes sickle cell?

Mutations in the HBB gene on chromosome 11 can cause sickle cell.

  • ID: 15968
  • Source: DNAi

15937. What causes beta-thalassemia?

The HBB gene encodes an important blood protein called beta globin. A person with beta-thalassemia carries a mutation in both copies of the HBB gene, completely halting production of the beta globin protein.

  • ID: 15937
  • Source: DNAi

15936. What is beta-thalassemia?

The HBB gene encodes an important blood protein called beta globin. A person with beta-thalassemia carries a mutation in both copies of the HBB gene, completely halting production of the beta globin protein.

  • ID: 15936
  • Source: DNAi

15907. Beta-thalassemia

The HBB gene encodes an important blood protein called beta globin.

  • ID: 15907
  • Source: DNAi

15532. Sickle cell anemia, 3D animation with narration

Sickle cell anemia is a genetic disease that affects hemoglobin, the oxygen transport molecule in the blood.

  • ID: 15532
  • Source: DNALC.DNAi

15498. Hemoglobin and sickle cell anemia, 3D animation with no audio

This animation shows hemoglobin proteins of a person with sickle cell anemia.

  • ID: 15498
  • Source: DNAi

15561. Katreece, sickle cell patient

Katreece (here at right) has sickle cell anemia. The causes of sickle cell have been known since the 1940s.

  • ID: 15561
  • Source: DNAi

16004. HBB/HBBS Structure Alignment

Alignment of the 3D structures of hemoglobin beta and sicklecell hemoglobin beta.

  • ID: 16004
  • Source: DNAi

15708. petri dish, nerve, red blood cells

Petri dish, nerve, red blood cells.

  • ID: 15708
  • Source: DNAi

15957. What is muscular dystrophy?

The DMD gene codes for a large protein called dystrophin that is necessary for muscle cells to maintain their shape.

  • ID: 15957
  • Source: DNAi