James Watson describes sequencing the human genome using markers and BACs, and Craig Venter explains using cDNA libraries, ESTs, and shotgun sequencing.
Shotgun sequencing and dealing with repeat sections.
15477. The public Human Genome Project: mapping the genome, sequencing, and reassembly. 3D animation.
The public Human Genome Project: mapping the genome, sequencing, and reassembly.
The DNA sequencing method developed by Fred Sanger forms the basis of automated "cycle" sequencing reactions today.
Genome Sequencing: Shotgun technique.
The finished sequence of the human genome was published in April, 2003.
Pat Brown talks about developing microarray technology for genome-wide analysis.
Leroy Hood talks about DNA sequencing.
Techniques to read the sequence of DNA, letter by letter, have been available since the 1970s. However, the massive task of sequencing the three billion basepairs of the human genome required machines that could read and interpret the data.
Commentators on the genome sequence (Human Genome Project). Top: William Clinton, Ewan Birney, John Sulston. Bottom: Jim Watson, Craig Venter.