Phoebus Levene (c. 1930)
After Miescher's discovery, other scientists found better ways to purify the new substance. Nuclein was a crude extract and contained a lot of proteins. Once the proteins were removed, the "pure" substance became known as deoxyribonucleic acid because of its sugar structure (ribose-based) and its properties (acidic nature). Scientists, such as Phoebus Levene, began deconstructing the DNA components. They found that DNA was essentially a long-chain molecule, made up of four different nucleotides, ribose sugar, and phosphate.
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- ID: 15672
- Source: DNALC.DNAi
Friedrich Miescher and Phoebus Levene research nuclein, protein. and DNA.
Because it contains the directions for assembling the components of the cell, DNA is often thought of as the "instruction book" for assembling life.
Blocks to bases, DNA Has Four Units.
Explore tetranucleotide combinations.
In this section learn that an activated protein is transported into the nucleus through a pore in the nuclear membrane.
Fred Sanger outlines DNA sequencing.
Phoebus Levene was an organic chemist in the early 1900's. He is perhaps best known for his incorrect tetranucleotide hypothesis of DNA.
Francis Crick describes RNA and its role and Paul Zamecnick explains protein synthesis.
Phoebus Levene's contributions -- the distinction between DNA and RNA.
Did Levene's tetranucleotide theory affect the development of ideas in the field of nucleic acid research?