Watson and Crick's Nature paper, Arthur Kornberg
Interviewee: Arthur Kornberg. Arthur Kornberg talks about Watson and Crick's Nature paper.
I read that pair of papers in Nature, I was impressed, it didn't alter my way of life an iota. And in fact there is a rather naive component in that paper, which assumed that once one put the individual A next to a T and successively each of the building blocks, somehow they'd link together spontaneously. And to anyone who'd worked with enzymes this was so naive, and impossible, because you depend in every chemical reaction in nature, even the hydration, adding water to carbon dioxide, on an enzyme to catalyze that reaction thousands of fold faster than it ordinarily would, and to direct it. And so we already knew that enzymes had to exist to catalyze and direct the assembly of a double helix.
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DNA base pairs
1953 picture of Francis Crick (L) and James Watson (R) walking along the backs of King's College in Cambridge.
James Watson and Francis Crick, Cambridge University, 1953
James Watson talks about how he and Francis Crick decided whose name went first on the 1953 paper.
The DNA molecule is shaped like a twisted ladder.
DNA as a double helix.
James Watson teamed up with Francis Crick to figure out the structure of DNA in 1953. With the secret of life revealed, Watson was intrigued by the prospect of manipulating living things.
James Watson and Francis Crick solved the structure of DNA. Other scientists, like Rosalind Franklin and Maurice Wilkins, also contributed to this discovery.
Linus Pauling's triple-helix model for DNA and the reaction to this incorrect model.
James Watson and Francis Crick's 1953 Nature paper.