Studying indigenous populations, Douglas Wallace
Interviewee: Douglas Wallace. Mitochondrial DNA research pioneer Douglas Wallace speaks about the populations he samples and the direct application of the research. (DNAi Location: Applications > Human origins > Gene genealogy >Tracing ancestries > Studying indigenous populations)
We go to every population, and we do a complete genealogy of all the people that we're working with. And we only take the people in the genealogy that can trace their origins back to the original people in that area. So once you've defined then, the correct sample, the population sample, then you have to ask the population whether they would be willing to be tested, and what we find, amazingly enough, is that there are very few people that don't want to know about their origins. In fact, this seems to be a very common theme across the world, and people are very excited to participate, once they understand what we are trying to do. Moreover, we can explain to them, that by understanding some of this genetic variation that's unique to their ancestry, it also can give insights to some of the common clinical problems that they have in their population. So we have a direct clinical application to their needs.
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Mitochondrial DNA research pioneer Douglas Wallace speaks about mitochondrial DNA and theories of human evolution.
Geneticist Douglas Wallace explains a method of mapping a population's history using the mutations accumulated by its members.
This illustration shows the two major mitochondrial DNA lineages. The lower branch includes only African populations. The upper branch has both African and non-African members.
Molecular geneticist Douglas Wallace talks about the way mitochondrial DNA is inherited.
Molecular geneticist Douglas Wallace talks about the origin of our mitochondria and the DNA within.
Mitochondrial DNA pioneer Douglas Wallace speaks about the movement of different populations out of Africa.
Mitochondrial DNA pioneer Douglas Wallace explains the movement of different lineages of humans from Africa into Europe and Asia.
Geneticist Kenneth Kidd explains his study of human DNA variation in nuclear chromosomes.
Geneticist Mark Stoneking, one of the authors of a controversial 1987 paper on mtDNA, talks about our common female ancestor.
Mitochondrial DNA pioneer Douglas Wallace talks about the migrations of people from Asia into the Americas.