Biology & 3D Animation Library

Early DNA Sequencing

Two sequencing techniques were developed independently in the 1970s. The method developed by Fred Sanger used chemically altered "dideoxy" bases to terminate newly synthesized DNA fragments at specific bases (either A, C, T, or G). These fragments are then size-separated, and the DNA sequence can be read.

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Fred Sanger,dna fragments,dna sequencing,dna sequence,1970s, Sanger Sequencing, amplification, dideoxy, chain termination, dideoxynucleotides, nucleotides

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  • Type: animation
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16036. Fred Sanger, 1975

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15479. Sanger method of DNA sequencing, 3D animation with narration

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15912. Sequencing DNA

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16515. Animation 23: A gene is a discrete sequence of DNA nucleotides.

Fred Sanger outlines DNA sequencing.

  • ID: 15922
  • Type: animation
  • Source: DNALC.DNAFTB

15921. Gel electrophoresis

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  • ID: 15922
  • Type: animation
  • Source: DNAi

15567. DNA sequence

Early sequencers used four different reactions to determine the placement of each of DNA's four bases - known as A, C, T & G - in the sequence.

  • ID: 15922
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15573. DNA sequencer

An image of a DNA sequencer.

  • ID: 15922
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