SHANK3 Gene :: CSHL DNA Learning Center

SHANK3 Gene

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The SHANK3 gene is associated with a number of cognitive disorders including autism.

The SHANK3 (SH3 and multiple ankyrin repeat domains 3) gene spans 60 kb and contains 22 exons. SHANK3 is associated with a number of severe cognitive deficits, including language and speech disorders, mental retardation, and autism. SHANK3 proteins interact with neuroligins, cell surface proteins that binds to synaptic membranes and facilitate neurotransmission.

SHANK3, gene, autism, autistic, mental, retardation, language, speech, neurotransmission, neuroligin

ID: 919
Source: DNALC.G2C

876. Autism Boundaries

Professor David Skuse discusses the importance of identifying autism symptoms. Failing to diagnose the disorder can disrupt their social and educational attainments.

ID: 876
Source: G2C

884. Background to Autism

Autism is a disorder in brain development that becomes apparent in earliest childhood. It is defined by problems in socialization, communication, and repetitive behaviors.

ID: 884
Source: G2C

913. FOXP2 Gene

FOXP2 is a gene associated with autism and language disorders.

ID: 913
Source: G2C

1369. NLGN4 Gene

Mutations in two members of the neuroligin family, NLGN3 and NLGN4, have been associated with autism and Asperger syndrome.

ID: 1369
Source: G2C

1132. Autism - Communication Symptoms

Children with autism often have poor communication skills. Here we can see an autistic child who uses another person’s hand as a play tool.

ID: 1132
Source: G2C

881. Hotspot for Autism Genes

Several lines of research are converging to show how opposing genetic pathways can lead to autism.

ID: 881
Source: G2C

1354. Autism (lesson)

Students learn about the symptoms associated with autism, explore the nature of 'normal' behavior, and can design a quasi-experiment to test a hypothesis about autism.

ID: 1354
Source: G2C