Treating bipolar disorder: the dopamine system
Professor Wayne Drevets describes how dopamine receptor antagonists can stop mania. Similarly, enhancing dopamine function can enhance depression.
One other type of information that has implicated the dopamine system in bipolar disorder has been treatment effects. So you can actually stop mania in its tracks sometimes by giving a dopamine receptor antagonist, and so thatâ€™s one of the ways weâ€™ll treat acute mania clinically. You can also enhance depression by giving some drugs that would enhance dopamine function, and so that would be another sort of indirect type of evidence that this dopamine system may be functioning too low in depression and too high in mania.
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Serotonin is the biochemical most commonly associated with depression. Professor Wayne Drevets discusses other systems including norepinephrine, glutamate, and dopamine.
An overview of bipolar disorder-related content on Genes to Cognition Online.
Professor Wayne Drevets discusses the amygdala, striatum, and prefrontal cortex as neural correlates of bipolar disorder. Mania and depression may link to the dopamine system.
Professor Wayne Drevets discusses the serotonin system in relation to depression. Drugs that block serotonin reuptake in the brain (SSRIs) are commonly used to treat depression.
Professor Wayne Drevets explains how positron emission tomography (PET) is used to examine biochemicals in the brain such as serotonin.
Many researchers are finding new ways to use drugs already available for treating depression.
A review of the symptoms, causes, diagnosis, and treatments of bipolar disorder.
Professor Jeffrey Lieberman discusses the differences between typical and atypical drugs that are used to treat schizophrenia.
Professor Wayne Drevets discusses specific types of learning deficits associated with depression. These may be caused by biochemical impairments in long-term potentiation.
Professor Wayne Drevets explains that specific glial cells known as oligodendrocytes may be decreased in the brains of individuals who have bipolar disorder or major depressive disorder.