Professor Wayne Drevets describes dendritic atrophy, which refers to reductions in the branching of neurons.
What I referred to as dendritic atrophy refers to the change in the branching of neurons. A neuron in many ways is shaped kind of like a tree, where the cell body of the neuron would be like the trunk of the tree, but then a lot of the volume is made up by the branches and then the leaves on the end of the branches. And so if you think about the neuron cell body as the trunk of the tree and then the dendritic branches like the branches of a tree, and then the synapses on the end of those dendritic trees like the leaves, what you see in both depression and repeated stress models is that branches have actually dropped off. So you have less branches. Then synapses have dropped off and so you have less leaves. And so it changes function through this remodeling of these neuron dendritic trees.
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Professor Wayne Drevets discusses specific types of learning deficits associated with depression. These may be caused by biochemical impairments in long-term potentiation.
Professor Wayne Drevets discusses ways in which lithium may affect bipolar disorder. It affects multiple neurotransmitter systems and may protect brain structures that are atrophied in bipolar disorder.
Professor Bruce McEwen discusses the remodeling of dendrites, which are affected by BDNF, TPA, cell-adhesion molecules, and a number of other factors.
Professor Bruce McEwen describes the interplay between reilience and stress, which can cause the brain to shrink or grow.
Professor Wayne Drevets introduces the diathesis-stress model, which describes the relationship between biology and stress, particularly in relation to mental illness.
An animation shows how drugs for SMA may be delivered via infusion into the spinal cord.
Professor Wayne Drevets discusses the ways in which stress can lead to depression. Research into interactions between stress and genes include a mutation in the serotonin transporter region.
Professor Wayne Drevets discusses the impact of neuroimaging on psychiatry - allowing clinicians to look at brain function or brain chemistry in patients.
An overview of bipolar disorder-related content on Genes to Cognition Online.
Professor Wayne Drevets discusses the serotonin system in relation to depression. Drugs that block serotonin reuptake in the brain (SSRIs) are commonly used to treat depression.