Functional genes and the human genome project
Doctor Thomas Insel points out that while the human genome project is largely complete, the real challenge lies in figuring out the function of each gene.
I remember when the human genome project was finished, I remember Sidney Brenner talking about it and saying, â€˜This is terrific. We have a huge directory with all the addresses.â€™ But you know he said, 'You know, functionally what this is, is sort of like having the white pages of the phone book and what we really need now will be the yellow pages; we need to know where are all the plumbers, where are all the electricians, where are all the mechanics because when something goes wrong you want to go to the yellow pages. You donâ€™t know necessarily where all the right candidates will be.â€™ I think an agenda for the field over the next several years will be actually developing those yellow pages, understanding how to provide the function and the interrelationships of all of the many parts of this genome. Of course, one of the things that most surprising for people in the last five years, and itâ€™s been almost exactly 5 years since the publication of the human genome project. We thought we had a pretty good sense, even within the white pages, of all the names and all the addresses. We had about 23 thousand genes and where they were located. Of course, what we are now realizing is that there are lots of other elements within the genome that were not cataloged, that weâ€™re still beginning to try to get some understanding of. All of these small RNAs, lots of other factors that are within all of the non-protein coding parts of the genome, and thatâ€™s going to be still a big challenge for us going forward.
human genome project, sidney brenner, phone book, yellow, white, pages, function, functional, genomics, thomas insel
15477. The public Human Genome Project: mapping the genome, sequencing, and reassembly. 3D animation.
The public Human Genome Project: mapping the genome, sequencing, and reassembly.
Sydney Brenner showed that mRNA was the unstable intermediate that carried the message from DNA to the ribosomes.
Doctor Thomas Insel points out that many cognitive disorders have a relatively early onset, and the challenge is to find out the relevant genetic, cellular, and neural correlates.
Jim Kent talks about junk DNA in the human genome.
Doctor Thomas Insel discusses the importance of two neuropeptides - oxytocin and vasopressin - in relation to attachment and social bonding.
Discovering protein function is the next step in understanding the human genome.
The media covered the progress and the difficulties of the Human Genome Project.
Professor David Porteous describes how his group is trying to uncover the function of the DISC1 gene.
Human Genome Project logo.
Dr. Ewan Birney is a bioinformatician and worked on the Human Genome Project.