Video 36: Tom Sargent, clip 2
Tom Sargent is the chief research microbiologist in Section on Vertebrate Development in the Laboratory of Molecular Genetics, NICHD, NIH.
research microbiologist, tom sargent, vertebrate development, molecular genetics, nichd, organisms, differentiated cells
- ID: 16744
- Source: DNALC.DNAFTB
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Part I: Theories on how organisms end up with differentiated cells.
Sargent's gene library and comparisons with today's gene chips.
Molecules that regulate development are similar in different organisms.
Why use other animal models to study development?
The cell as a micro-computer that can interpret signals for different responses.
Tom Sargent did some of the first differential gene expression studies using cDNA subtraction.
Igor Dawid did some of the first differential gene expression studies using cDNA subtraction.
Professor David Van Vactor explains that model systems are simple organisms that allow us to study and manipulate gene function and development.
The domesticated chicken is a modern descendant of dinosaurs. It is the premier non-mammalian model organism and provides a new perspective on vertebrate genome evolution.
Model organisms share with humans many key biochemical and physiological functions that have been conserved (maintained) by evolution.