A database of genomes, Robert Sinsheimer
Interviewee: Robert Sinsheimer. Robert Sinsheimer, then chancellor of the University of California, Santa Cruz, brought experts together in 1985 to discuss the possibility of a Human Genome Project. He talks about his idea. (DNAi Location: Genome > The project > Players > Pros & cons > Was biology missing something?)
It had occurred to me to wonder whether, were we missing something in biology? Was there something we weren't doing in biology, because we didn't think in terms of big science? It seemed so successful in other fields. We didn't need a big machine like an accelerator or like a telescope, but it did occur to me that maybe we could use a big database like a database of genomes, and sequences of genomes.
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Jim Kent talks about a farm of computers.
Jim Kent talks about dealing with sequencing data.
Eric Lander, director of the Whitehead Institute Center for Genome Research, talks about the mistaken notion of the Human Genome Project as "big science."
Robert Sinsheimer talks about the feasability of sequencing the human genome.
An image of telomeres. Courtesy of Robert Moyzis, University of California, Irvine, CA; U.S. Department of Energy Human Genome Program
Nobel Laureate James Watson, the first director of the Human Genome Project, talks about his first reaction to the idea.
Ewan Birney talks about processing sequencing data.
Ari Patrinos, director of the US Department of Energy's sequencing effort, talks about the public genome project's aims that extended beyond those of the private project.
Roy Britten did seminal research on repetitive DNA and its evolutionary origins.