Chromosome 5: genes involved in asthma and other allergies, Matt Ridley
Interviewee: Matt Ridley. There are more than five chromosomal regions linked with asthma. The relative roles of genes at these locations are not clear, but genes on chromosome 5 and chromosome 20 are promising areas for investigation. Asthma is a chronic lung disease that causes the lining of a person's airways to swell, tighten and inflame when exposed to different irritants or triggers. (DNAi Location: Genome > Tour > Genome spots > Chromosomes 5 & 20, Asthma > A chromosome 5 story)
Many scientists are searching for the genes involved in asthma and other allergies. One of the candidate genes is here on chromosome 5. But asthma is not going to be a simple matter of finding one gene that causes the disease; it's affected by lots of different genes, and of course it's affected by things that happen in the environment, too, like pollution or other things in our lives. What the genes involved in asthma do is increase the likelihood that we will respond to environmental triggers, or decrease it. The environment and genes are always interacting.
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There are more than five chromosomal regions linked with asthma.
Matt Ridley talks about chromosome 20, gene for adenosine deaminase.
Matt Ridley talks about chromosome 4, Huntington's Disease.
Matt Ridley talks about chromosome 15, Prader-Willi's disease, or Angelman's syndrome
Matt Ridley talks about chromosome 19, APOE gene and susceptibility to Alzheimer's.
Matt Ridley talks about chromosome 6, HLA genes and the human immune system.
Matt Ridley talks about Y Chromosome, SRY gene responsible for the masculinization process.
Matt Ridley talks about chromosome 18, BCL2 oncogene.
Matt Ridley talks about chromosome 3, gene associated with alkaptonuria.
Matt Ridley talks about chromosome 2, fusion of 2 small chromosomes.