About the CREB Gene
Professor Ron Davis explains that the gene CREB is important to memory. Blocking CREB expression, blocks short-term memory formation.
One of the molecules that is particularly important for long-term memory is a molecule called CREB. Itâ€™s a repressor of gene expression in the genome. And of one of the principle and important findings that has been made is in Drosophila with this molecule dCREBb because if one over expresses it in the brain, one can shut down the expression of genes. And that blocks not the formation and the expression of short-term memories, but it blocks long-term memories. So it was really very nice evidence showing this particular molecule is critical for the formation of long-term memories specifically.
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CAMP response element-binding protein 2(CREB2) is also known as Activating Transcription Factor 2 (ATF2). CREB2 is a CREB repressor, which means it inhibits long-term memory formation.
Professor Ron Davis explains that short-term memories are formed by recruiting new synapses. It is unknown whether long-term memories are formed in the same way.
An interactive chromosome map of the genes and loci associated with learning and memory.
Professor Ron Davis discusses how his lab observed that short term memories are formed through the recruitment of new synapses.
Professor Ron Davis describes how memories are formed through the addition of new synapses.
The cAMP response element-binding protein 1 (CREB1) gene is a CREB activator and has been found to facilitate long-term memory formation.
Learning and memory are two intimately linked cognitive processes that stem from interactions with the environment (experience).
Professor Ron Davis discusses the attributes that make the fruit fly a good model for studying memory in humans.
Professor Ron Davis discusses exciting future directions in memory research.
Communication in brain cells is guided by interactions between genes and biochemicals at the synapse. These interactions can lead to the formation of new synapses.