EHMT2/A0444

Euchromatic histone-lysine N-methyltransferase 2 (EHMT2, also known as A0444) exists in a range of isoforms produced by alternative splicing. The gene can be found on human chromosome 6.

Euchromatic histone-lysine N-methyltransferase 2 (EHMT2, also known as A0444) exists in a range of isoforms produced by alternative splicing. The gene can be found on human chromosome 6. EHMT2 methylates lysine amino acids of histone H3, and it belongs to the family of histone-lysine methyltransferases. This methylation represents a specific tag for epigenetic transcriptional repression by recruiting heterochromatin protein 1 (HP1) proteins to methylated histones. EHMT2 is widely expressed with particularly high levels in foetal liver, thymus, lymph node and spleen tissues and peripheral blood leukocytes and at lower levels in bone marrow. EHMT2 mutant mice embryos display severe growth retardation and early lethality.

  • ID: 1858
  • Source: DNALC.G2C